Predictive Role of the Systemic Immune Inflammation Index in the Progression of Non-Dialysis Chronic Kidney Disease
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0614
- VernacularTitle:全身免疫炎症指数对非透析慢性肾脏病进展的预测作用
- Author:
Leile TANG
1
;
Jianhao KANG
2
;
Shaomin LI
2
;
Ying DENG
2
;
Xun LIU
2
Author Information
1. Department of Cardiology， The Third Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510630， China
2. Department of Nephrology， The Third Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510630， China
- Publication Type:Journal Article
- Keywords:
systemic immune inflammatory index;
chronic kidney disease;
non-dialysis;
progression;
predictive effect
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(6):1041-1049
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveOur study seeks to investigate the connection between systemic immune inflammatory index and renal function， as well as to assess its predictive capacity for the deterioration of renal function in chronic kidney disease patients with non-dialysis. MethodsAdult non-dialyzing patients diagnosed with CKD were included. The computation of SII was calculated as the product of the peripheral blood neutrophil count （×10⁹/L） and platelet count （×10⁹/L）， divided by the lymphocyte count （×10⁹/L）. The logistic and Cox regression models were employed to scrutinize the linkage between SII levels and CKD. ResultsOut of the cohort， a significant portion of patients， numbering 244， which constitutes 17.2%， experienced progression of CKD. A notable upsurge in SII corresponded with an increased prevalence of advanced CKD and its progression， with significant difference. This trend was mirrored by a decline in the estimated glomerular filtration rate and hemoglobin levels， while serum creatinine， C-reactive protein， and lipoprotein（a） levels were on the rise. After adjusting for multiple variables， the natural logarithm of SII exhibited an independent association with advanced CKD ［OR=1.85 95% CI（1.46，2.35），P＜0.01］. Furthermore， Cox proportional hazards model analysis revealed that SII acted as an independent predictor for CKD progression ［adjusted HR= 1.35， 95% CI（1.09，1.67）， P＜ 0.01］. Subgroup analysis indicated a significant interaction among SII， gender， and hypertension concerning CKD progression. ConclusionOur findings underscore the robust relationship between SII and renal function， positioning SII as a potential forecaster for the progression of CKD.
