Research Progress on Changes of Mitochondrial Quality Control System in Ischemic Stroke and Acupuncture Therapy
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0605
- VernacularTitle:缺血性脑卒中线粒体质量控制系统的改变及针刺治疗的研究进展
- Author:
Yiran PENG
1
;
Ruiqing LI
1
Author Information
1. Rehabilitation Center， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
- Publication Type:Review
- Keywords:
acupuncture;
mitochondrial quality control;
ischemic stroke;
neuroprotection;
mitochondrial homeostasis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(6):955-963
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke （IS） is a cerebrovascular disease caused by thrombosis or embolism that interrupts cerebral blood flow， resulting in brain tissue damage. Mitochondria serve as the primary site for energy metabolism and are also involved in key biological processes， including calcium signal regulation， reactive oxygen species generation， and apoptosis initiation. Therefore， the structural and functional integrity of mitochondrial is crucial for neuronal survival， and the mitochondrial quality control （MQC） system is fundamental for maintaining mitochondrial homeostasis. The MQC system maintains mitochondrial network homeostasis by synergistically regulating key processes such as biogenesis， dynamics balance （fusion and fission）， autophagy， oxidative stress clearance， and calcium homeostasis. However， following IS， neurons undergo pathological changes-including inflammatory responses， oxidative stress， and excitatory amino acid toxicity- due to ischemia and hypoxia. These factors collectively disrupt mitochondrial membrane potential and inhibit electron transport chain function， leading to MQC dysfunction. Recent studies have confirmed that acupuncture can restore MQC homeostasis after IS through multiple targets and pathways， specifically including promoting mitochondrial biogenesis， balancing mitochondrial fission and fusion， regulating mitochondrial autophagy， reducing oxidative stress damage， and inhibiting calcium overload. This article systematically reviews the relationship between MQC and IS， with a focus on elucidating the mechanistic basis of acupuncture-mediated IS treatment via regulating key MQC components. These findings provide a theoretical basis for the efficacy of acupuncture in IS management and offer novel perspectives for developing future stroke therapeutic strategies targeting MQC pathways.
