Advances on the Regulation of Programmed Cell Death by Non-coding RNAs in Chronic Kidney Disease
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0602
- VernacularTitle:非编码RNA调控细胞程序性死亡影响慢性肾脏病的研究进展
- Author:
Daoyu SHENG
1
;
Ying DING
1
Author Information
1. Pediatric Hospital of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Review
- Keywords:
chronic kidney disease;
non-coding RNA;
apoptosis;
autophagy;
pyroptosis;
ferroptosis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(6):920-934
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease （CKD） is a common disease with high morbidity and mortality. Increasing evidence has indicated that programmed cell death （PCD） plays a significant role in the pathogenesis and progression of CKD. Non-coding RNA （ncRNA）， defined as a category of RNA that lacks coding potential， has emerged as a pivotal regulator of gene expression. This regulatory function of ncRNA extends to various biological processes， including PCD. This paper reviews the recent advances on the involvement of ncRNAs in the regulation of apoptosis， autophagy， pyroptosis， ferroptosis， necroptosis， and PANoptosis in CKD. It explores the crosstalk between different pathways and categorizes therapeutic strategies targeting ncRNA regulation of PCD into three main areas： the active ingredients of traditional Chinese medicine， tissue engineering technologies， and drugs. The objective of this study is to identify novel therapeutic targets and strategies for clinical treatment.
