Analysis of the interaction between circadian rhythm and other influencing factors in age-related macular degeneration
10.3980/j.issn.1672-5123.2026.1.09
- VernacularTitle:年龄相关性黄斑变性中的昼夜节律与其他影响因素的交互作用分析
- Author:
Ziyang WU
1
;
Wenjun ZOU
1
Author Information
1. Jiangnan University Medical Center;Wuxi No.2 People's Hospital, Wuxi 214000, Jiangsu Province, China; Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
circadian rhythms;
age-related macular degeneration;
photoreceptor cells;
retina
- From:
International Eye Science
2026;26(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm(CR)is an intrinsic biological clock mechanism within organisms that regulates physiological and biochemical processes, enabling synchronization with periodic fluctuations in the external environment. This rhythmicity not only influences the sleep-wake cycle but also encompasses various physiological functions, including metabolism, hormone secretion, cell proliferation, and immune responses. Age-related macular degeneration(ARMD), a prevalent retinal disease, has been significantly associated with disruptions in CR. ARMD is among the leading causes of vision loss in the elderly, with a complex pathogenesis involving multiple factors such as genetics, environmental influences, and lifestyle choices. This article will focus on the molecular mechanisms linking CR and ARMD, analyzing how disruptions in CR affect the physiological state and metabolic processes of retinal cells, ultimately contributing to the onset and progression of ARMD. Additionally, this article will elucidate the interactions effects of CR on ARMD in relation to oxidative stress, regulation of Aβ, inflammatory pathways, and mitochondrial homeostasis. By deepening our understanding of the relationship between CR and ARMD, we aim to provide new insights and directions for future clinical interventions and treatments.
