Active Ingredients of Bupleuri Radix in Treatment of Central Nervous System： A Review
10.13422/j.cnki.syfjx.20251039
- VernacularTitle:柴胡活性成分治疗中枢神经系统的研究进展
- Author:
Shuhuan YANG
1
;
Xin JIANG
1
;
Runda YUAN
1
;
Fang LU
2
Author Information
1. Graduate School， Heilongjiang University of Chinese Medicine， Harbin 150040，China
2. Institute of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine， Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
Bupleuri Radix;
Alzheimer's disease;
Parkinson's disease;
epilepsy;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(2):325-334
- CountryChina
- Language:Chinese
-
Abstract:
Diseases of the central nervous system have become a growing global health concern. At present， there are many adverse reactions in the treatment with Western medicine. In contrast， traditional Chinese medicine has shown unique efficacy and rich clinical practice accumulation in diseases of the central nervous system. As a traditional Chinese medicine， Bupleuri Radix has played an important role in the treatment of neurological diseases through multi-target regulation， multi-pathway intervention， and multi-pathway mechanism of action. In recent years， with the in-depth study of the pharmacological effects of Bupleuri Radix， it has been found that the active ingredients such as saikosaponin， baicalin， quercetin， and kaempferol in Bupleuri Radix can be used as the main material basis for the treatment of neurological diseases. The results of this study showed that in neurodegenerative diseases， active ingredients of Bupleuri Radix can inhibit β-amyloid （Aβ） deposition and abnormal phosphorylation of microtubule-associated protein （Tau protein） in Alzheimer's disease， regulate the nuclear factor-κB/nuclear factor E2 related factor 2 （NF-κB/Nrf2） pathway to play the anti-inflammatory role， and alleviate α-Synuclein （α-Syn） aggregation and mitochondrial damage in Parkinson's disease. In epilepsy， depression， and cerebral ischemia， they can improve symptoms by regulating neurotransmitters， oxidative stress， and apoptosis pathways， and inhibit brain glioma proliferation. However， the mechanism of action has not been fully elucidated， and the complexity of compound components and poor blood-brain barrier penetration limit their clinical application. In the future， it is necessary to integrate multi-omics， network pharmacology， and nano-delivery technologies， focus on the optimization of active ingredient group compounds and the precise guidance of biomarkers， accelerate the development of innovative therapies for Alzheimer's disease， Parkinson's disease， and other diseases for laying a solid theoretical foundation for further development and application and inspiring new research ideas.
