Mechanism of Action of Guishenwan in Treatment of Ovarian Insufficiency Diseases： A Review
10.13422/j.cnki.syfjx.20252102
- VernacularTitle:归肾丸治疗卵巢功能减退性疾病的作用机制研究进展
- Author:
Yao CHEN
1
;
Sainan TIAN
1
;
Bin'an WANG
2
;
Shengyu WANG
2
;
Wen'e LIU
1
;
Lei LEI
1
;
Li TANG
1
Author Information
1. The First Hospital of Hunan University of Chinese Medicine， Changsha 410007， China
2. School of Traditional Chinese Medicine， Hunan University of Chinese Medicine， Changsha 401208， China
- Publication Type:Journal Article
- Keywords:
Guishenwan;
diminished ovarian reserve;
premature ovarian insufficiency;
premature ovarian failure;
mechanism research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(2):317-324
- CountryChina
- Language:Chinese
-
Abstract:
Guishenwan （GSW）， originating from Jingyue Quanshu （Zhang Jingyue's Complete Works）， is a classic traditional Chinese medicine （TCM） formula with a history of over 400 years. Designed for kidney essence deficiency syndrome， it is clinically applied to treat diseases associated with essence-blood deficiency， such as ovarian insufficiency diseases in women， oligospermia-induced infertility in men， and lumbar disc herniation. Numerous studies have confirmed its significant efficacy and advantages in managing ovarian insufficiency diseases， including diminished ovarian reserve （DOR）， premature ovarian insufficiency （POI）， and premature ovarian failure （POF）. According to recent literature， the therapeutic mechanisms of GSW in treating ovarian insufficiency diseases involve regulating the hypothalamic-pituitary-ovarian axis （HPOA） function， ameliorating reproductive endocrine disorders， improving ovarian function， modulating relevant signaling pathways， and exerting immunoregulatory and anti-inflammatory effects. A review of GSW in clinical treatment revealed that clinical applications of GSW， particularly in combination with Western medicine， not only alleviate symptoms but also compensate for the limitations of hormone replacement therapy， thereby reducing recurrence， minimizing adverse reactions， and enhancing safety. This review aims to provide a scientific basis for the rational clinical use of GSW in ovarian insufficiency diseases， offer innovative TCM strategies for developing novel ovarian-protective drugs， promote the integration of TCM and Western medicine in reproductive medicine， and ultimately contribute a Chinese approach to global management of ovarian insufficiency diseases.
