Clinical Application and Pharmacological Effects of Guizhi Fulingwan in Treatment of Uterine Fibroids： A Review
10.13422/j.cnki.syfjx.20250425
- VernacularTitle:桂枝茯苓丸治疗子宫肌瘤的临床应用与药理作用研究进展
- Author:
Xiang ZHANG
1
;
Xiaoli WEN
1
;
Biting CHENG
1
;
Hongning LIU
1
Author Information
1. Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi University of Chinese Medicine， Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
uterine fibroids;
Guizhi Fulingwan;
abdominal mass;
clinical application;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(2):299-307
- CountryChina
- Language:Chinese
-
Abstract:
Uterine fibroids are a common benign tumor of the female reproductive system， characterized by increased menstrual flow， lower abdominal pain， and prolonged menstrual periods. Modern medicine believes that the onset of this disease is related to genetic factors， environmental factors， hormone levels， et al， while the specific mechanism remains unclear， and the prevention and treatment of uterine fibroids has become a hot topic of concern for many experts and scholars in the medical field. At present， the treatment of uterine fibroids in clinical practice is mainly based on hormone drugs and uterine artery embolization， and severe cases require hysterectomy. However， the use of hormone drugs for treatment has serious side effects and is prone to recurrence after surgery. Since hysterectomy can cause severe harm to women， it is necessary to explore safer and more effective treatment methods. Traditional Chinese medicine （TCM） has rich clinical experience in the treatment of uterine fibroids， advocating for syndrome differentiation and treatment. The TCM methods that regulate Qi and blood and balance Yin and Yang have been commonly adopted， with significant efficacy and minimal side effects， being more conducive to the recovery. Guizhi Fulingwan are first recorded in the Synopsis of the Golden Chamber written by the famous medical expert ZHANG Zhongjing during the Eastern Han dynasty. This prescription has the effects of activating blood， resolving stasis， and eliminating mass， and it is thus mainly used for treating abdominal mass in women. In recent years， Guizhi Fulingwan has also been applied in the clinical treatment of tumors and has demonstrated definite efficacy in the treatment of uterine fibroids. Studies have shown that the therapeutic mechanisms of Guizhi Fulingwan for uterine fibroids involve regulating cell proliferation and apoptosis， improving immune function， reducing inflammation， improving hemorheological indicators， inhibiting tumor angiogenesis， and regulating sex hormone levels. This article mainly reviews the treatment of uterine fibroids with Guizhi Fulingwan from three aspects： theoretical basis， clinical application， and pharmacological mechanism. It is expected to provide scientific research ideas and guidance for exploring the clinical treatment of uterine fibroids.
