Effect of Traditional Chinese Medicine Monomers and Compounds on Regulating JAK/STAT Signaling Pathway in Rheumatoid Arthritis Treatment： A Review
10.13422/j.cnki.syfjx.20250626
- VernacularTitle:中药单体及复方调控JAK/STAT信号通路治疗类风湿关节炎的研究进展
- Author:
Xiaonan YAN
1
;
Jigao LI
1
;
Ruixiang YANG
2
;
Ruilin LIU
1
;
Quan ZHOU
1
;
Zhen LI
3
;
Yan LIU
4
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2. Xinxiang Central Hospital，Xinxiang 453000，China
3. Luoyang Branch of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine，Luoyang Hospital of Traditional Chinese Medicine，Luoyang 471000，China
4. School of Traditional Chinese Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
Janus kinase/signal transducer and activator of transcription （JAK/STAT）;
rheumatoid arthritis;
traditional Chinese medicine monomer;
traditional Chinese medicine compound;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(2):289-298
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis （RA） is a common chronic systemic autoimmune disease with synovitis as the main manifestation， which often causes joint swelling and pain or even deformity. It is considered to be an incurable lifelong disease. Although the current Western medicine treatment can alleviate the progression of the disease， it has the clinical limitations of liver injury， cardiovascular complications， and other adverse reactions， along with easy recurrence. Traditional Chinese medicine （TCM） has a long history and has the advantages of individualized treatment and fewer adverse reactions. It can effectively relieve the symptoms of joint swelling and pain in RA patients and slow down the progression of bone destruction， which has attracted wide concern in the medical community. Janus kinase （JAK）/signal transducer and activator of transcription （STAT） signaling pathway is an important intracellular pathway involved in cell proliferation， differentiation， apoptosis， immune regulation， and other biological behaviors， and plays an important role in the pathophysiological process of RA. In recent years， many studies have confirmed that TCM monomers and compounds can inhibit inflammation and angiogenesis by regulating the JAK/STAT signaling pathway， induce apoptosis and inhibit proliferation of fibroblast-like synoviocytes （FLS）， regulate immune response， and thus exert an effect in the treatment of RA. However， there is still a lack of comprehensive and systematic induction and overview. Therefore， by searching the relevant literature in China National Knowledge Infrastructure （CNKI） and PubMed databases from 2009 to 2024， this study described the mechanism of the JAK/STAT signaling pathway in the occurrence and development of RA and summarized the research progress of TCM monomers and compounds in regulating the JAK/STAT signaling pathway in RA intervention. The study aims to provide new ideas and strategies for the clinical treatment of RA with TCM and the research and development of new drugs.
