Combined Therapy of Traditional Chinese and Western Medicine for Hepatitis B Virus Infection： A Review
10.13422/j.cnki.syfjx.20260198
- VernacularTitle:中西医联合抗乙型肝炎病毒感染的研究进展
- Author:
Xuan WU
1
;
Hui LI
1
;
Jian HUANG
1
;
Xikun YANG
1
;
Yan ZENG
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610072，China
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
integrated traditional Chinese and Western medicine;
antiviral;
novel drug research and development;
synergy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(2):279-288
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus （HBV） infection is the primary cause of viral hepatitis and represents a substantial disease burden in China. However， effective and safe agents capable of completely eliminating HBV DNA are still lacking. In modern medicine， anti-HBV strategies mainly target covalently closed circular DNA （cccDNA）， among other mechanisms， and multiple novel drugs are currently under clinical investigation. Traditional medicine has been shown to exert anti-HBV effects through direct pathways， such as blocking viral entry， as well as indirect pathways， including the regulation of programmed cell death. Studies have confirmed that the integration of traditional Chinese medicine （TCM） and Western medicine in treating HBV infection and its related complications offers complementary advantages， particularly in enhancing HBV clearance rates， improving liver function， preventing various complications， and delaying the progression from hepatic fibrosis to hepatocellular carcinoma. This review focuses on advances in anti-HBV research involving TCM， Western medicine， and their integrated application， aiming to provide a basis for integrated HBV therapy and new drug development.
