Processing History and Modern Research of Bile-processed Coptidis Rhizoma： A Review
10.13422/j.cnki.syfjx.20251667
- VernacularTitle:胆黄连的炮制历史沿革及现代研究进展
- Author:
Zhaowei DONG
1
;
Jing YANG
2
;
Qinwan HUANG
3
;
Jin WANG
4
Author Information
1. School of Chinese Classics，Chengdu University of Traditional Chinese Medicine（TCM）， Chengdu 611137，China
2. Digital Key Laboratory of Excavated Medical Literature and Cultural Relics Protection Research，Chengdu University of TCM，Chengdu 611137，China
3. School of Pharmacy，Chengdu University of TCM，Chengdu 611137，China
4. School of Ethnic Medicine，Chengdu University of TCM，Chengdu 611137，China
- Publication Type:Review
- Keywords:
bile-processed Coptidis Rhizoma;
processing history;
synergistic effect;
quality evaluation;
material basis;
pharmacological effects and medicinal properties
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(2):269-278
- CountryChina
- Language:Chinese
-
Abstract:
Bile-processed Coptidis Rhizoma（B-pCR）， first documented in Shengji Zonglu， is a unique processed products of Coptidis Rhizoma（CR） characterized by "mutual enhancement processing" and "enhancing the cold property of cold-natured herbs". Pig bile can enhance the bitter and cold properties of CR， yielding potent effects in purging excess fire from the liver and gallbladder. The processing increases the dissolution of alkaloids such as berberine， coptisine， and palmatine， while introducing bile acids from pig bile， including taurine-type and glycine-type cholic acids. This enhances its pharmacological effects， such as antipyretic activity， regulation of glucose and lipid metabolism disorders， and intestinal absorption. Traditional processing techniques and quality standards for B-pCR are outlined in the Shanghai Traditional Chinese Medicine（TCM） Decoction Pieces Processing Standard and the Gansu TCM Processing Standard. However， incomplete specifications for critical process parameters and quality criteria significantly impact its production and clinical application. A review of research over the past two decades on the processing history， process optimization， quality evaluation， material basis， and changes in pharmacological effects and properties of B-pCR reveals that the pretreatment method and dosage of pig bile， and processing temperature are key factors influencing its quality. Furthermore， current quality standards lack specific indicators. Additionally， the enhancement of the cold property and medicinal efficacy direction of B-pCR is not only associated with changes in alkaloid groups but also depend on the synergistic effects of bile acids. This review can provide insights for improving the quality evaluation system of B-pCR.
