Mechanism of action of the Notch signaling pathway in mediating immune inflammatory response in liver injury

VernacularTitle:Notch信号通路介导免疫炎症反应参与肝损伤的作用机制
Author: Faming SHU ¹ ; Ying HUANG ² ; Kan ZHANG ¹ ; Fajuan HE ¹ ; Fuli LONG ¹ ; Dewen MAO ¹
Author Information

1. Department of Hepatology， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China
2. Department of Traditional Chinese Medicine， International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine， Nanning 530200， China
Publication Type:Review
Keywords: Liver Injury; Receptors， Notch; Pathologic Processes
From: Journal of Clinical Hepatology 2025;41(11):2424-2428
CountryChina
Language:Chinese
Abstract: Immune inflammatory response runs through the whole pathological process of liver injury， but its specific regulatory mechanism remains unclear. Recent studies have shown that the Notch signaling pathway plays an important role in liver injury by regulating macrophage polarization， activating neutrophil recruitment， and modulating the differentiation of regulatory immune cells. This article systematically reviews the molecular mechanisms of the Notch signaling pathway in mediating immune inflammatory response in liver injury， in order to provide new perspectives for clarifying the molecular mechanism of immune inflammatory damage in liver diseases， as well as a new reference for future research directions.