Role of neutrophil extracellular traps in hepatocellular carcinoma

Xueru TIAN; Weiyu CHEN; Luyi YAN; Yang HONG; Han WANG; Shouqin LIU; Lei QING; Guojuan MA; Dewen MAO; Chun YAO

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Role of neutrophil extracellular traps in hepatocellular carcinoma

VernacularTitle:中性粒细胞外陷阱在肝细胞癌中的作用
Author: Xueru TIAN ¹ ; Weiyu CHEN ¹ ; Luyi YAN ¹ ; Yang HONG ¹ ; Han WANG ² ; Shouqin LIU ¹ ; Lei QING ¹ ; Guojuan MA ¹ ; Dewen MAO ³ ; Chun YAO ⁴
Author Information

1. Graduate School， Guangxi University of Chinese Medicine， Nanning 530020， China
2. Department of Internal Medicine， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China
3. First Ward of Hepatology， The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530023， China
4. Guangxi University Engineering Research Center for Innovative Product Development of Regional Major Diseases， Guangxi University of Chinese Medicine， Nanning 530020， China
Publication Type:Review
Keywords: Carcinoma，Hepatocellular; Neutrophil Extratrapping; Pathologic Processes
From: Journal of Clinical Hepatology 2025;41(11):2410-2417
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma （HCC） is a malignant tumor with high incidence and mortality rates worldwide. Recent studies have shown that neutrophil extracellular traps （NETs） play an important role in the development， progression， and immune escape of HCC. NETs are released by neutrophils and mainly consist of DNA， histones， and antimicrobial molecules， and in addition to immune defense， they are also involved in the initiation， metastasis， and thrombosis of HCC. This article elaborates on the formation and regulatory mechanisms of NETs， explores their potential mechanisms in the initiation， metastasis， immune escape， and thrombosis of HCC， and discusses the prospect of NETs as a target for the diagnosis and treatment of HCC， in order to provide new ideas for the precise treatment of HCC in the future and promote the early diagnosis and effective treatment of HCC.