The impact of iron overload and ferroptosis on the development and progression of autoimmune hepatitis and their mechanism of action

VernacularTitle:铁过载和铁死亡对自身免疫性肝炎发生发展的影响及作用机制
Author: Bolin WANG ¹ ; Ling LI ¹ ; Jinxia ZHU ² ; Jiawen ZHANG ¹ ; Zhigao LUO ¹ ; Guangwei LIU ²
Author Information

1. Third Ward of Spleen， Stomach and Hepatobiliary Department， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
2. Department of Hepatology， Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 200032， China
Publication Type:Review
Keywords: Hepatitis， Autoimmune; Iron Overload; Ferroptosis
From: Journal of Clinical Hepatology 2025;41(11):2384-2389
CountryChina
Language:Chinese
Abstract: Autoimmune hepatitis （AIH） is an inflammatory disease caused by immune dysfunction， and its pathogenic mechanism remains unclear. In recent years， a large number of studies have shown that iron homeostasis imbalance and ferroptosis are closely associated with the pathogenesis and progression of AIH. This article reviews the pathological mechanism and impact of iron overload and ferroptosis in AIH， in order to provide new insights and theoretical bases for research on the mechanism and clinical treatment of AIH.