Research advances in the reprogramming of glucose and lipid metabolism in liver fibrosis： Targeting hepatic macrophages and hepatic stellate cells
- VernacularTitle:肝纤维化中糖脂代谢重编程研究进展： 靶向肝巨噬细胞与肝星状细胞
- Author:
Xikun YANG
1
;
Hui LI
1
;
Kaixin WANG
1
;
Xuan WU
1
Author Information
- Publication Type:Review
- Keywords: Liver Fibrosis; Hepatic Macrophage; Hepatic Stellate Cell; Metabolic Reprogramming
- From: Journal of Clinical Hepatology 2025;41(11):2379-2383
- CountryChina
- Language:Chinese
- Abstract: Liver fibrosis has a complex pathogenesis， and as research deepens， an increasing number of evidence has revealed extensive metabolic reprogramming in the development and progression of liver fibrosis. This article reviews the origin and role of hepatic macrophages， the distribution of hepatic stellate cells， and the changes in glycolysis and lipid metabolism in the two types of cells， in order to provide new insights into the research on liver fibrosis and the prevention and treatment of this disease.
