Influence of NOD-like receptor protein 3 inflammasome on the development and progression of nonalcoholic steatohepatitis and the interventional effect of traditional Chinese medicine

Jinxue ZHANG; Junhong LIU; Jiale CHEN; Dan WANG; Lining SU; Yajie CHEN; Xueqian LAI; Miaolei WANG; Yajing LI

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Influence of NOD-like receptor protein 3 inflammasome on the development and progression of nonalcoholic steatohepatitis and the interventional effect of traditional Chinese medicine

VernacularTitle:NOD样受体蛋白3（NLRP3）炎症小体对非酒精性脂肪性肝炎发生发展的影响及中医药的干预作用
Author: Jinxue ZHANG ¹ ; Junhong LIU ² ; Jiale CHEN ¹ ; Dan WANG ¹ ; Lining SU ¹ ; Yajie CHEN ¹ ; Xueqian LAI ³ ; Miaolei WANG ² ; Yajing LI ²
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1. School of Integrated Traditional Chinese and Western Medicine， Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Department of Spleen and Stomach Diseases， The Affiliated Hospital of Gansu University of Chinese Medicine， Lanzhou 730000， China
3. Pediatric Emergency Center Branch II， Gansu Provincial Central Hospital， Lanzhou 730000， China
Publication Type:Review
Keywords: Non-alcoholic Fatty Liver Disease; NLR Family， Pyrin Domain-Containing 3 Protein; Drugs， Chinese Herbal; Drug Therapy
From: Journal of Clinical Hepatology 2025;41(11):2365-2371
CountryChina
Language:Chinese
Abstract: Nonalcoholic steatohepatitis （NASH） is a chronic liver disease with the main pathological features of hepatic steatosis， inflammatory cell infiltration， and interstitial fibroplasia， and it is an important risk factor for liver fibrosis， liver cirrhosis， and hepatocellular carcinoma. NOD-like receptor protein 3 （NLRP3） inflammasome is the core of innate immunity， and the abnormal activation of NLRP3 inflammasome is closely associated with the development and progression of NASH， which involves multiple links such as inflammatory response and oxidative stress. A large number of studies have shown that the active ingredients of traditional Chinese medicine （TCM） and TCM compound prescriptions can improve oxidative stress， regulate lipid metabolism， and alleviate liver inflammation by regulating NLRP3 inflammasome. TCM treatment applied in clinical practice has achieved a good therapeutic effect， while inflammasome is one of the key pathways or targets for TCM in improving NASH. This article reviews the mechanism of action of NLRP3 inflammasome in NASH and the research advances in TCM intervention of NLRP3 inflammasome， in order to provide ideas for the clinical TCM treatment of NASH， as well as reference targets and research directions for the research and development of new TCM drugs.