Study on pathogenesis and new therapy of enterovirus-associated autoimmunity diseases
10.13200/j.cnki.cjb.004615
- VernacularTitle:肠道病毒相关自身免疫病的发生机制及其新疗法探讨
- Author:
Yilin JIANG
1
Author Information
1. Central Laboratory, Lequn Campus, First Hospital of Jilin University, Changchun 130031, Jilin Province, China
- Publication Type:Journal Article
- Keywords:
Autoimmunity disease(AID);
Enterovirus(EV) infection;
Type 1 diabetes(T1D);
Inflammatory bowel disease(IBD);
Coeliac disease
- From:
Chinese Journal of Biologicals
2025;38(12):1516-1521+1529
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmunity diseases(AIDs) involve the entire body's tissue systems and pose a serious threat to the normal immune system and health of the human body. Researches have shown that AID is caused by the complex interaction between genetic susceptibility and environmental factors. Enterovirus(EV) infection often accompanies certain AID and is an important type of virus infection related to AID. Coxsackievirus(CV), a member of the EV family, is an important pathogen among the pathogenic factors of type 1 diabetes(T1D). EV infection causes damage to the activity of pancreatic β cells and accelerates the disease progression of T1D. In terms of treatment, recent reports have shown that antiviral therapy for T1D is effective in preserving the function of β pancreatic cells. In celiac disease and Crohn's disease(CD), EV infection can induce inflammatory pathogenic changes in the intestinal microbiota, increase intestinal barrier permeability, and may trigger the occurrence of such AIDs. However, the relationship and mechanism between EV infection and many AIDs remain unclear.This paper summarizes the research conclusions on the correlation between EV infection and AIDs to facilitate a deeper exploration of their pathogenic patterns.
