Molecular mechanism of cerebellin family regulating synapse formation and research progress on it in prevention and treatment of neurological diseases
10.13200/j.cnki.cjb.004625
- VernacularTitle:小脑蛋白家族调控突触形成的分子机制及其在神经疾病防治中的研究进展
- Author:
Jinfeng DU
1
Author Information
1. Shanghai GeneoDx Biotech Co., Ltd., Shanghai 200231, China
- Publication Type:Journal Article
- Keywords:
Cerebellin family;
Synapse;
Neural circuit
- From:
Chinese Journal of Biologicals
2025;38(12):1504-1509+1515
- CountryChina
- Language:Chinese
-
Abstract:
The development of the nervous system and functional recovery following injury critically depend on synaptic involvement, with synaptic plasticity regulation serving as the foundational mechanism underpinning neural development,functional maintenance, and repair. The cerebellin(Cbln) protein family, widely distributed synaptic organizers in the brain,mediates specific interactions between secreted proteins and receptors to drive synapse assembly, maintenance, and neural circuit formation, thereby achieving synaptic plasticity modulation. Notably, dysfunction of this family is closely associated with multiple neurological disorders. This paper reviews the mechanistic roles of Cbln family members in synaptic molecular regulation, signal transduction, and neural network construction, providing comprehensive and detailed clues for the study of cerebellin family and valuable research perspectives for the prevention and treatment of related neurological diseases.
