Research progress on immunomodulatory effects and role of bile acids and bile acid receptors in the occurrence and development of colorectal cancer
10.12206/j.issn.2097-2024.202312024
- VernacularTitle:胆汁酸和胆汁酸受体的免疫调节作用及其在结直肠癌发生发展中的研究进展
- Author:
Zhijun LIU
1
;
Lili CUI
2
;
Fengjing XU
2
;
Xinhua SONG
2
;
Zhipeng WANG
2
;
Shouhong GAO
1
Author Information
1. College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China;Department of Pharmacy, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
2. Department of Pharmacy, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
- Publication Type:Reviews
- Keywords:
colorectal cancer;
bile acids;
bile acid receptor;
immunoregulation
- From:
Journal of Pharmaceutical Practice and Service
2025;43(12):583-590
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is one of the most common malignant tumors, which is a great threat to human life and health. The change of bile acid homeostasis can activate their corresponding receptors to regulate the immune functions, which is closely related to the occurrence of colorectal cancer. In addition, some bile acids can directly induce colorectal cancer and play an important role in the development of colorectal cancer. In this paper, the metabolic process of bile acids in vivo and the immunomodulatory role of bile acid receptors were reviewed, and the evidence of associations between bile acids and colorectal cancer were summarized, which showed the rebalancing the bile acid levels might play a role in the prevention or treatment of colorectal cancer.
