Advances in the Studies of MicroRNA-1976 in Aberrant Cell Cycle Diseases.
10.3881/j.issn.1000-503X.16376
- Author:
Hao-Yu JI
1
;
Hao CHEN
1
;
Liang SHI
2
;
Meng ZHANG
1
;
Ting CHEN
1
;
Ying-Ming KONG
1
;
Rong-Ke FENG
1
Author Information
1. Department of Neurology,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,China.
2. Department of Histology and Embryology,School of Basic Medicine,Shanxi Medical University,Jinzhong,Shanxi 030619,China.
- Publication Type:Review
- Keywords:
aberrant cell cycle;
cancer;
central nervous system disease;
microRNA-1976
- MeSH:
MicroRNAs/genetics*;
Humans;
Cell Cycle/genetics*;
Neoplasms/genetics*;
Central Nervous System Diseases/genetics*
- From:
Acta Academiae Medicinae Sinicae
2025;47(4):644-650
- CountryChina
- Language:English
-
Abstract:
Most tumor cells and healthy neurons are at rest during G0 phase.Once the cell cycle is abnormally re-entered under certain conditions,the proliferation of tumor cells and the degenerative necrosis of neurons can be initiated.From the perspective of the cell cycle,cancer and central nervous system diseases,two seemingly different disease types,have a common pathogenesis.This type of diseases is named aberrant cell cycle diseases.As a newly discovered microRNA(miR),miR-1976 is closely related to the regulation of the cell cycle.This review summarizes the progress in the research on miR-1976 in cancer and central nervous system diseases,aiming to provide a reference for the clinical application of miR-1976 in aberrant cell cycle diseases in the future.
