Research Progress in the Function and Regulation of Sirtuin 3 in Sepsis-Related Diseases.
10.3881/j.issn.1000-503X.16371
- Author:
Jun-Jie LI
1
;
Hong MEI
2
;
Xin-Xin LIU
1
;
Kun YU
1
;
Bang-Hai FENG
2
;
Bao FU
1
;
Song QIN
1
Author Information
1. Department of Critical Care Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China.
2. Department of Critical Care Medicine,Zunyi Traditional Chinese Medicine Hospital,Zunyi,Guizhou 563000,China.
- Publication Type:Review
- Keywords:
multiple organ dysfunction;
sepsis;
sirtuin 3
- MeSH:
Sepsis/metabolism*;
Sirtuin 3/physiology*;
Humans;
Animals;
Oxidative Stress;
Mitochondria/metabolism*;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2025;47(4):601-610
- CountryChina
- Language:English
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection,with a high mortality rate.Sirtuin 3,a deacetylase within mitochondria,plays an important regulatory role in cellular metabolism,oxidative stress,and inflammatory responses.In recent years,significant progress has been made in the study of the function and regulatory role of sirtuin 3 in sepsis-related diseases.Research has shown that sirtuin 3 can alleviate organ damage caused by sepsis by regulating mitochondrial function,reducing oxidative stress,and inhibiting inflammatory responses.The specific mechanisms include the regulation of mitochondrial bioenergetics,activation of antioxidant enzyme systems,and inhibition of inflammatory mediator expression.In addition,sirtuin 3 plays a protective role in the pathological process of sepsis by interacting with multiple signaling pathways.This article summarizes the functions and regulatory mechanisms of sirtuin 3 in various sepsis-related diseases,aiming to provide new targets and strategies for the prevention and treatment of sepsis in the future.
