Untargeted Metabolomics of Plasma From Coronavirus Disease 2019 Patients One Year After Recovery.
10.3881/j.issn.1000-503X.16347
- Author:
Xu-Tong ZHANG
1
;
Ye-Hong YANG
1
;
Yue WU
1
;
Rong HAN
1
;
Qiao-Chu WANG
1
;
Tao DING
1
;
Jiang-Feng LIU
1
;
Jun-Tao YANG
1
Author Information
1. State Key Laboratory of Common Mechanism Research for Major Diseases,Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China.
- Publication Type:Journal Article
- Keywords:
coronavirus disease 2019;
recovery;
severe acute respiratory syndrome coronavirus 2;
untargeted metabolomics
- MeSH:
Humans;
COVID-19/metabolism*;
Metabolomics;
SARS-CoV-2;
Metabolome;
Female;
Male;
Adult;
Middle Aged
- From:
Acta Academiae Medicinae Sinicae
2025;47(4):519-526
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the recovery of plasma metabolism in asymptomatic and mild patients of coronavirus disease 2019(COVID-19)one year after recovery.Methods A total of 174 participants were recruited from the communities in Wuhan,including 80 healthy volunteers and the COVID-19 patients who had recovered for one year.According to the disease severity,the recovered COVID-19 patients were grouped as asymptomatic patients(n=80)and mild patients(n=14).The liquid chromatography mass spectrometry platform was employed to study the metabolomic characteristics of the plasma from all the participants.Results The plasma metabolites in asymptomatic patients and mild patients remained abnormal compared with those in healthy volunteers.Among the differential metabolites in asymptomatic patients and mild patients,some metabolites showed a downward trend only in mild patients,such as phosphatidylethanolamine[20∶3(5Z,8Z,11Z)/P-18∶0],sphingomyelin(d18∶1/24∶0),and cholesteryl(15∶0).The metabolic pathway involving the differential metabolites in mild patients was mainly glycerophospholipid metabolism.Conclusions Even one year after recovery,the mild COVID-19 patients still exhibit metabolic abnormalities.Hence,these patients may experience an extended period of time for recovery.
