Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease.
10.3881/j.issn.1000-503X.16279
- Author:
Ye LIAO
1
;
Yun-Feng ZHOU
2
;
Xiao-Rui ZHOU
1
;
Xin HU
3
;
Juan LIAO
4
;
Lu LONG
1
Author Information
1. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China.
2. Departments of Thoracic Surgery,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China.
3. Shiyang Community Health Service Center,Chengdu Hi-Tech Zone,Chengdu 610041,China.
4. Department of Gastroenterology,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China.
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
gastroesophageal reflux disease;
prospective study
- MeSH:
Humans;
Pulmonary Disease, Chronic Obstructive/epidemiology*;
Gastroesophageal Reflux/epidemiology*;
Middle Aged;
Proportional Hazards Models;
Incidence;
Male;
Risk Factors;
Female;
Aged
- From:
Acta Academiae Medicinae Sinicae
2025;47(3):402-407
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the association between gastroesophageal reflux disease(GERD)and the risk of incident chronic obstructive pulmonary disease(COPD)and explore potential effect modifiers influencing this association.Methods Clinical data from 476 175 participants in the UK Biobank(2006-2010)were collected.A Cox proportional hazards model was used to assess the relationship between GERD and the risk of incident COPD.Subgroup analyses were conducted to examine potential modifiers of the primary findings.Results A total of 11 587(2.43%)new COPD cases were diagnosed.The Cox proportional hazards model revealed that GERD was associated with an increased risk of incident COPD(HR=1.59,95%CI=1.46-1.74,P<0.001).GERD was linked to a higher risk of incident COPD in individuals aged<60 years(P<0.001)and non-smokers(P=0.011).No association was observed between GERD and the risk of incident COPD in current smokers with a daily cigarette consumption<10 cigarettes(P=0.261).Conclusion GERD may increase the risk of incident COPD.
