Langerhans Cell Histiocytosis of Bone:Report of Eight Cases and Review of the Literature.
10.3881/j.issn.1000-503X.16077
- Author:
Ya BI
1
;
Dan-Dan WU
1
;
Fang-Ying YU
1
;
Zhen-Hong FANG
1
;
Bo HUANG
1
Author Information
1. Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563003,China.
- Publication Type:Case Reports
- Keywords:
Langerhans cell histiocytosis of bone;
diagnosis;
immunohistochemistry;
treatment
- MeSH:
Humans;
Bone Diseases/therapy*;
Histiocytosis, Langerhans-Cell/therapy*
- From:
Acta Academiae Medicinae Sinicae
2025;47(2):325-332
- CountryChina
- Language:English
-
Abstract:
Langerhans cell histiocytosis of bone is a rare tumor disease characterized by the large accumulation of CD1a+ and CD207+ dendritic cells in tissues of unknown cause.It mainly occurs in children aged 1-4 years old,with incidences of 4-6 per million in children and 1-2 per million in adults.Due to its low incidence,diverse clinical manifestations,and no obvious specificity of imaging manifestations,the definitive diagnosis and early treatment of this type of tumor are challenging.In this paper,we report 8 cases of Langerhans cell histiocytosis of bone and review the relevant literature published in the past five years to summarize the clinical characteristics,pathological features,diagnosis,treatment,and prognosis of this disease.
