Advances in the Localization and Regulation of P-glycoprotein in Different Tissues and Organs.
10.3881/j.issn.1000-503X.16156
- Author:
Jia-Hua ZHAO
1
;
Xiao-Sa YANG
2
;
Xiao-Jiao XU
1
;
Rui LIU
1
;
Tian-Tian ZHUANG
2
;
Jia-Tang ZHANG
2
Author Information
1. School of Medicine,Nankai University,Tianjin 300071,China.
2. Department of Neurology,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China.
- Publication Type:Review
- Keywords:
P-glycoprotein;
localization;
molecular structure;
regulation;
transport mechanism
- MeSH:
Humans;
ATP Binding Cassette Transporter, Subfamily B, Member 1/chemistry*;
Animals;
Drug Resistance, Multiple
- From:
Acta Academiae Medicinae Sinicae
2025;47(2):295-302
- CountryChina
- Language:English
-
Abstract:
P-glycoprotein(P-gp)is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cell to the outside of the cell to maintain a stable endo-environment.However,it meanwhile restricts the entry of therapeutic drug into tissues and organs,and in particular,mediates the multidrug resistance of tumor cells to chemotherapeutic drugs.Therefore,understanding the localization of P-gp in different tissues and organs may be an important breakthrough point for disease treatment.In this paper,we mainly review the molecular structure,transport mechanism,localization,and regulation of P-gp in different tissues and organs,providing reference for the subsequent treatment of diseases.
