Research Progress in the Role of Testosterone in Male Depression.
10.3881/j.issn.1000-503X.16142
- Author:
Jia-Min FU
1
;
Qi GUO
2
;
Xiao-Yu CHEN
2
Author Information
1. College of Sports and Health,Tianjin University of Sport,Tianjin 301600,China.
2. College of Rehabilitation Sciences,Shanghai University of Medicine and Health Sciences,Shanghai 200093,China.
- Publication Type:Review
- Keywords:
androgen deprivation therapy;
depression;
hypogonadism;
testosterone;
testosterone replacement therapy
- MeSH:
Humans;
Testosterone/physiology*;
Male;
Depression/etiology*;
Hormone Replacement Therapy
- From:
Acta Academiae Medicinae Sinicae
2025;47(2):274-280
- CountryChina
- Language:English
-
Abstract:
As the social pressure is increasing,the incidence of depression is growing.Testosterone is synthesized and secreted through the hypothalamic-pituitary-gonadal axis,which plays a regulatory role in men's mental health.Studies have shown that low testosterone levels,clinical hypogonadism,and androgen deprivation therapy-induced testosterone deficiency are significantly associated with male depression,while there are still many uncertainties about the mechanism of their effects.Given that low testosterone levels may serve as a characteristic biomarker of male depression risk,testosterone replacement therapy may have a good therapeutic effect on male depression.This article focuses on assessing the role of testosterone levels and related clinical therapies in mood regulation in men.
