Efficacy and Safety of Systemic Thrombolysis in the Treatment of Lower Extremity Fracture Complicated With Distal Deep Vein Thrombosis.
10.3881/j.issn.1000-503X.16171
- Author:
Shi-Qiang LIAO
1
;
Shu-Ming SHI
1
;
Qiang ZHANG
1
;
Chuan-Yong LI
1
;
Guang-Feng ZHENG
1
;
Zhi-Chang PAN
1
;
Jian-Jie RONG
1
Author Information
1. Department of Vascular Surgery,Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Suzhou,Jiangsu 215003,China.
- Publication Type:Journal Article
- Keywords:
anticoagulant therapy;
distal deep vein thrombosis;
lower extremity fracture;
thrombolytic therapy
- MeSH:
Humans;
Venous Thrombosis/therapy*;
Retrospective Studies;
Thrombolytic Therapy/methods*;
Male;
Female;
Middle Aged;
Fractures, Bone/complications*;
Lower Extremity/injuries*;
Anticoagulants/therapeutic use*;
Aged;
Treatment Outcome;
Adult
- From:
Acta Academiae Medicinae Sinicae
2025;47(2):237-243
- CountryChina
- Language:English
-
Abstract:
Objective To evaluate the efficacy and safety of systemic thrombolysis(ST)and standard anticoagulation(SA)in the treatment of lower extremity fracture complicated with distal deep vein thrombosis(DDVT).Methods We retrospectively analyzed the clinical data of 60 patients with lower extremity fracture complicated with DDVT treated from January 2021 to December 2023.When the lower limb venography indicated a calf thrombus burden score ≥3 points,a retrievable inferior vena cava filter(IVCF)was successfully placed in the healthy femoral vein before orthopedic surgery.The patients who received further anticoagulant or thrombolytic therapy after surgery were allocated into a ST group(n=30,urokinase ST and SA)and a SA group(n=30,only SA).The two groups were compared in terms of calf thrombus burden score,thrombus dissolution rate,IVCF placement time,IVCF retrieval rate,intercepted thrombi,hemoglobin level,platelet count,D-dimer level,and complications.Results There was no statistically significant difference in the calf thrombus burden score between the two groups before treatment(P=0.431).However,after treatment,the scores in both groups decreased(both P<0.001),with the ST group showing lower score than the SA group(P=0.002).The thrombus dissolution rate in the ST group was higher than that in the SA group(P<0.001).There was no statistically significant difference in the IVCF placement time between the two groups(P=0.359),and the IVCF retrieval rate was 100% in both groups.The ST group had fewer intercepted thrombi than the SA group(P=0.002).There was no statistically significant difference in hemoglobin level(P=0.238),platelet count(P=0.914),or D-dimer level(P=0.756)between the two groups before treatment.However,after treatment,both groups showed an increase in platelet count(both P<0.001)and a decrease in D-dimer level(both P<0.001).There was no statistically significant difference in the occurrence of complications between the two groups(P=0.704).Conclusions Both SA and ST demonstrate safety and efficacy in the treatment of lower extremity fractures complicated with DDVT,serving as valuable options for clinical application.Compared with SA,ST not only enhances the thrombus dissolution in the calf but also mitigates the risk of thrombosis associated with IVCF.
