Altered Cerebral Blood Flow in Type 2 Diabetes Mellitus Without Cognitive Impairment.
10.3881/j.issn.1000-503X.16155
- Author:
Jia-Ying YANG
1
;
Xue-Wei ZHANG
2
;
Xue-Qing LIU
1
;
Jia-Min ZHOU
1
;
Miao HE
1
;
Jing LI
3
;
Xia-Li SHAO
4
;
Wen-Hui LI
5
;
Yu-Zhou GUAN
6
;
Wei-Hong ZHANG
1
;
Feng FENG
1
Author Information
1. Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. Department of Interventional Radiology,Emergency General Hospital,Beijing 100020,China.
3. Department of Neurology,The First Affiliated Hospital of Tsinghua University,Beijing 100016,China.
4. Department of Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China.
5. Department of Endocrinology,,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
6. Department of Neurology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- Keywords:
arterial spin labeling;
cerebral blood flow;
type 2 diabetes mellitus
- MeSH:
Humans;
Diabetes Mellitus, Type 2/physiopathology*;
Cerebrovascular Circulation;
Middle Aged;
Male;
Female;
Magnetic Resonance Imaging;
Case-Control Studies;
Cognitive Dysfunction;
Neuropsychological Tests;
Aged
- From:
Acta Academiae Medicinae Sinicae
2025;47(2):219-225
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the alterations of cerebral blood flow(CBF)in type 2 diabetic mellitus(T2DM) patients without cognitive impairment by using arterial spin labeling(ASL)technique.Methods A total of 23 T2DM patients without cognitive impairment and 23 healthy controls(HC)matched by age,sex,and education attainment were recruited.Their clinical data were collected,and neuropsychological tests and cerebral magnetic resonance imaging were performed.Then,the outcomes of clinical features,neuropsychological tests,and global and regional CBF were compared between the two groups.The significant regional zCBF(z-transformed relative CBF)values were extracted and correlated with clinical data and neuropsychological scores in T2DM patients,controlling age,sex,and education.Results No significant difference was found in whole brain CBF between the two groups(P=0.155),while significantly higher CBF was identified in the left superior temporal gyrus and left insula in the T2DM group(Gaussian random field correction,initial threshold P < 0.001,cluster level P < 0.05).No correlation was observed between the significant regional zCBF values and the clinical data or the neuropsychological scores in T2DM patients(all P>0.05).Conclusion Alterations in cerebral hemodynamics may precede cognitive function changes in T2DM,suggesting that the ASL technique is promising for early monitoring of cerebral hemodynamic changes associated with cognitive impairment in patients with T2DM.
