Research Progress in Effect of Repetitive Noxious Stimuli in Neonatal Period on Neural Development.
10.3881/j.issn.1000-503X.16266
- Author:
Yan LI
1
;
Wen-Yu ZHANG
1
;
Zhi XIAO
2
;
Xing-Feng LIU
2
Author Information
1. Graduate School,Zunyi Medical University,Zunyi,Guizhou 563000,China.
2. Key Laboratory of Brain Science,Guizhou Institution of Higher Education,Zunyi Medical University,Zunyi,Guizhou 563000,China.
- Publication Type:Review
- Keywords:
hyperalgesia;
neonate;
pain;
repetitive noxious stimuli;
synaptic remodeling
- MeSH:
Humans;
Infant, Newborn;
Brain/growth & development*;
Infant, Premature;
Intensive Care Units, Neonatal;
Hyperalgesia;
Pain
- From:
Acta Academiae Medicinae Sinicae
2025;47(5):843-849
- CountryChina
- Language:English
-
Abstract:
The establishment and development of neonatal intensive care unit(NICU)have significantly increased the survival rate of premature infants.However,the diagnosis,treatment,and surgeries performed in NICU may expose neonates to more noxious stimuli.As the neonatal period is crucial for brain development,these noxious stimuli may cause irreversible damage to the neonatal nervous system.Existing clinical studies have shown that repetitive noxious stimuli during the neonatal period can lead to poor brain development,persistent hyperalgesia,and various sequelae.However,the underlying mechanisms remain unclear,and effective treatment methods are lacking.This article summarizes the effects of repetitive noxious stimuli during the neonatal period on neural development and the complications,aiming to provide a basis for the neonatal analgesia management and the prevention and treatment of related sequelae.
