Metagenomic Next-Generation Sequencing-Assisted Diagnosis of Japanese Spotted Fever: Report of One Case.

Author: Yong-Chun RUAN ¹ ; Yi-Qing ZHOU ¹ ; Hai-Wang ZHANG ¹ ; Jie ZHOU ¹ ; Jin-Nan DUAN ¹ ; Xiao-Jing ZHANG ² ; L I MING-HUI ¹
Author Information

1. Department of Infectious Diseases,Shaoxing People's Hospital,Shaoxing,Zhejiang 312000,China.
2. WillingMed Technology(Beijing)Company Limited,Beijing 100023,China.
Publication Type:Journal Article
Keywords: Japanese spotted fever; diagnosis; metagenomic next-generation sequencing
MeSH: Humans; High-Throughput Nucleotide Sequencing; Metagenomics; Rickettsia/isolation & purification*; Spotted Fever Group Rickettsiosis/microbiology*
From: Acta Academiae Medicinae Sinicae 2025;47(1):146-149
CountryChina
Language:English
Abstract: Japanese spotted fever(JSF)is an infectious disease caused by Rickettsia japonica,with nonspecific clinical symptoms and a high risk of misdiagnosis.We reported a case of JSF,in which Rickettsia japonica was detected in blood cells by metagenomic next-generation sequencing.The patient recovered after treatment with doxycycline.This report provides a reference for the clinical diagnosis and treatment of JSF.