Research Progress in Metabolism-Related Diseases and Formation Mechanism of Calcium Oxalate Stones.
10.3881/j.issn.1000-503X.16038
- Author:
Wei-Hu CEN
1
;
Jun SHEN
1
;
Sha-Sha XIA
1
;
Qiang WANG
1
Author Information
1. Department of Urology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China.
- Publication Type:Review
- Keywords:
calcium oxalate stone;
mechanism;
metabolism-related diseases;
reactive oxygen species
- MeSH:
Humans;
Calcium Oxalate/metabolism*;
Kidney Calculi/etiology*;
Metabolic Diseases/complications*
- From:
Acta Academiae Medicinae Sinicae
2025;47(1):124-130
- CountryChina
- Language:English
-
Abstract:
Kidney stones are a urinary system disease with a high incidence,among which calcium oxalate stones are the most common.Metabolic disorders such as hypertension,diabetes,obesity,hyperlipidemia,and hyperuricemia can cause changes in oxalate,uric acid,and pH and calcium ion concentrations in the urine through multiple pathways including inducing oxidative stress and inflammatory responses by generating reactive oxygen species,ultimately affecting the formation of calcium oxalate stones.This article reviews the possible pathways and mechanisms by which metabolic diseases influence the formation of calcium oxalate stones,providing new ideas for the clinical prevention and treatment of calcium oxalate stones.
