Research Progress in Copper Homeostasis and Diseases.
10.3881/j.issn.1000-503X.15884
- Author:
Shu-Ting QIU
1
;
Xiao-Hua TAN
1
;
Shi-Han SHAO
1
;
Li YU
1
;
Ying-Ying ZHANG
1
;
Yue-Jia CAO
1
;
Di CHUN-HONG
2
Author Information
1. School of Public Health,Hangzhou Normal University,Hangzhou 311121,China.
2. Department of Clinical Laboratory,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China.
- Publication Type:Journal Article
- Keywords:
cancer;
copper homeostasis;
copper metabolism;
cuproptosis
- MeSH:
Humans;
Copper/metabolism*;
Homeostasis;
Neoplasms/metabolism*;
Hepatolenticular Degeneration/metabolism*;
Menkes Kinky Hair Syndrome/metabolism*
- From:
Acta Academiae Medicinae Sinicae
2025;47(1):102-109
- CountryChina
- Language:English
-
Abstract:
As an indispensable trace element in the human body,copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the occurrence of related diseases.Cuproptosis,a newly proposed regulatory cell death mode,is different from the known apoptosis,pyroptosis,necroptosis,and ferroptosis.Recent studies have found that the dyshomeostasis of copper has been observed in a variety of cancers.Therefore,targeting copper for disease treatment may become a new strategy and a new idea.This article systematically summarizes the fundamental properties of copper,copper dyshomeostasis-related diseases (Menkes syndrome,Wilson's disease,and cancer) and their treatment,and reviews the research progress in cuproptosis.
