Research Progress in Effects of Vermiform Appendix on the Occurrence and Development of Diseases Related to Gut-Brain Axis.
10.3881/j.issn.1000-503X.16046
- Author:
Mo SHU-TING
1
;
Tian ZHE
1
;
Lei XIN
1
;
Chao HAN
2
;
Yu-Hua CHEN
1
Author Information
1. Graduate School,Bengbu Medical University,Bengbu,Anhui 233030,China.
2. Department of Neurology,The First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China.
- Publication Type:Review
- Keywords:
Alzheimer’s disease;
Parkinson’s disease;
inflammatory bowel disease;
microbiota-gut-brain axis;
multiple sclerosis;
vermiform appendix
- MeSH:
Humans;
Appendix/anatomy & histology*;
Brain;
Appendicitis;
Appendectomy/adverse effects*;
Gastrointestinal Microbiome;
Brain-Gut Axis
- From:
Acta Academiae Medicinae Sinicae
2025;47(1):95-101
- CountryChina
- Language:English
-
Abstract:
The gut-brain axis is a bidirectional communication pathway connecting the central nervous system and gastrointestinal tract,playing a key role in the occurrence and development of diseases related to this axis.The vermiform appendix,as a part of the gut that is connected to the cecum,has a unique anatomical location,a rich microbiome,and abundant immune cells.Appendicitis and appendectomy have been found to be associated with the development of diseases related to the gut-brain axis.This review first introduces the anatomy and functions of the vermiform appendix and then expounds the associations of appendicitis and appendectomy with diseases related to the gut-brain axis.Furthermore,this review summarizes and prospects the mechanisms of the vermiform appendix in affecting the occurrence and development of diseases related to the gut-brain axis.
