Current Progress of 5-Methylcytosine RNA Methylation in Non-Neoplastic Kidney Diseases.
10.3881/j.issn.1000-503X.16053
- Author:
Chen ZHANG
1
;
Zi-Xia ZHAO
1
;
Wu SI
1
;
Jun-Jun LUAN
1
;
Hua ZHOU
1
Author Information
1. Department of Nephrology,Shengjing Hospital of China Medical University,Shenyang 110000,China.
- Publication Type:Review
- Keywords:
5-methylcytosine;
RNA;
RNA methylation;
epigenetics;
kidney diseases
- MeSH:
Humans;
Methylation;
5-Methylcytosine/metabolism*;
Kidney Diseases/metabolism*;
Epigenesis, Genetic;
RNA Methylation
- From:
Acta Academiae Medicinae Sinicae
2025;47(1):86-94
- CountryChina
- Language:English
-
Abstract:
RNA methylation is a key process in the epigenetic regulation of post-transcriptional gene expression.5-Methylcytosine(m5C)is a type of RNA methylation,commonly existing in eukaryotic mRNA and non-coding RNAs.It mainly regulates transfer RNA stability,ribosomal RNA assembly,and mRNA translation,stability,and translation.RNA methylation is dynamically reversible and regulated by methyltransferase,demethylase,and methylation recognition protein.It has been confirmed that aberrant m5C RNA methylation is involved in the pathogenesis of non-neoplastic kidney diseases.This article summarizes the current progress of m5C RNA methylation associated with non-neoplastic acute and chronic kidney diseases,aiming to provide potential targets for the diagnosis and treatment of such diseases.
