Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review.
10.3881/j.issn.1000-503X.16114
- Author:
Tian GAO
1
;
Yong ZHANG
2
;
Dan ZHANG
1
;
Ping ZENG
3
Author Information
1. Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China.
2. Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China.
3. Health and Medical Department,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Review
- Keywords:
microenvironment;
muscle satellite cell;
sarcopenia;
skeletal muscle stem cell
- MeSH:
Sarcopenia/physiopathology*;
Humans;
Satellite Cells, Skeletal Muscle/physiology*;
Muscle, Skeletal/physiopathology*;
Aging/physiology*;
Animals;
Stem Cells
- From:
Acta Academiae Medicinae Sinicae
2024;46(6):958-964
- CountryChina
- Language:English
-
Abstract:
Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.Skeletal muscle stem cells,also known as muscle satellite cells,play a key role in supporting muscle regeneration and homeostasis maintenance.Studies have suggested that muscle satellite cell functions are tightly regulated by microenvironment signals in the skeletal muscle.Of note,skeletal muscle fibers,serving as an immediate niche of muscle satellite cells,regulate their activation,proliferation,and self-renewal.This article reviews the research progress in the regulatory roles of skeletal muscle stem cells and their microenvironment in sarcopenia during aging,providing theoretical support for potential treatment of sarcopenia via modifying skeletal muscle microenvironment and regulating muscle satellite cell functions.
