Research Progress on Obesity-Associated Kidney Diseases.
10.3881/j.issn.1000-503X.16098
- Author:
Rui-Feng YANG
1
;
Wen WU
2
;
Peng ZHANG
3
Author Information
1. Department of Nephrology, The Sixth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 201306,China.
2. Department of General Surgery, The Sixth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 201306,China.
3. Department of Bariatric and Metabolic Surgery,Beijing Friendship Hospital, Capital Medical University,Beijing 100050,China.
- Publication Type:Review
- Keywords:
obesity;
obesity-associated kidney disease;
pathogenesis;
treatment strategy
- MeSH:
Humans;
Obesity/complications*;
Kidney Diseases/therapy*;
Renin-Angiotensin System;
Insulin Resistance
- From:
Acta Academiae Medicinae Sinicae
2025;47(1):77-85
- CountryChina
- Language:English
-
Abstract:
The pathogenesis of obesity-associated kidney disease (OAKD) involves many aspects,including the overactivation of the renin-angiotensin-aldosterone system,insulin resistance,chronic inflammation,disorder of lipid metabolism and imbalance of gut microecology.Treatment strategies for OAKD focus on lifestyle adjustments,pharmacotherapy,bariatric surgery,and fecal microbiota transplantation.A deeper understanding of the hazards of OAKD and its pathogenesis will contribute to the development of personalized and precise strategies for prevention,diagnosis and treatment of OAKD in the future.
