Advances in the antimicrobial substances in <i>Bacillus</i>.

Tiantian FAN; Aoxue WANG; Yutong LIU; Shumei ZHANG; Zhengfeng SONG; Xiuling CHEN

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Advances in the antimicrobial substances in Bacillus.

Author: Tiantian FAN ¹ ; Aoxue WANG ¹ ; Yutong LIU ² ; Shumei ZHANG ³ ; Zhengfeng SONG ⁴ ; Xiuling CHEN ¹
Author Information

1. College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, Heilongjiang, China.
2. Heilongjiang Agricultural Engineering Vocational College, Harbin 150088, Heilongjiang, China.
3. Institute of Microbiology, Heilongjiang Academy of Sciences, Harbin 150010, Heilongjiang, China.
4. Shandong Province Shouguang City Sanmu Seedling Co., Ltd., Shouguang 262700, Shandong, China.
Publication Type:English Abstract
Keywords: Bacillus; antimicrobial substances; application prospects; biosynthesis; synthesis gene clusters
MeSH: Bacillus/genetics*; Anti-Infective Agents/metabolism*; Bacterial Proteins/genetics*; Antimicrobial Peptides/biosynthesis*; Lipopeptides/biosynthesis*
From: Chinese Journal of Biotechnology 2025;41(10):3667-3682
CountryChina
Language:Chinese
Abstract: Bacillus is a class of spore-producing Gram-positive bacteria that produce a variety of antimicrobial substances with different structures and functions. The application of the antimicrobial substances produced by Bacillus can effectively inhibit the activity of harmful bacteria and fungi and promote the sustainable development of green agriculture. The antimicrobial substances produced by Bacillus mainly include proteins, lipopeptides, polyketones, and polypeptides. This paper reviews the synthesis gene clusters, synthesis pathways, structures, and mechanisms of various antimicrobial substances produced by Bacillus and discusses the challenges in the industrial application of these antimicrobial substances. Furthermore, this paper clarifies the future research and development focuses and prospects the application prospects, and provides comprehensive theoretical support for the in-depth research and wide application of the antimicrobial substances produced by Bacillus.