Research progress in application of field effect transistor biosensors in virus detection.
- Author:
Li HE
1
;
Zhongming LIU
1
;
Huan YANG
1
;
Yating LI
1
;
Haiyan ZHANG
1
Author Information
- Publication Type:English Abstract
- Keywords: biosensor; field effect transistor; nucleic acid detection; point of care testing (POCT); virus detection
- MeSH: Biosensing Techniques/instrumentation*; Transistors, Electronic; Humans; SARS-CoV-2/isolation & purification*; Viruses/isolation & purification*; Orthomyxoviridae/isolation & purification*; Hepatitis Viruses/isolation & purification*; Virus Diseases/virology*; HIV/isolation & purification*; COVID-19/diagnosis*
- From: Chinese Journal of Biotechnology 2025;41(8):3021-3035
- CountryChina
- Language:Chinese
- Abstract: Viral infections are one of the main causes of deaths and economic losses around the globe, and effective virus detection methods are essential for epidemic prevention and control. Most existing detection methods have problems such as high false negative/positive rates, slow responses, high costs, and dependence on professional equipment and personnel, which are not conducive to the rapid and accurate detection of viruses. Field effect transistor (FET) biosensors have attracted widespread attention due to their advantages of label-free detection, high sensitivity, fast responses, real-time measurement, low power consumption, and small sizes for portability. This article first briefly describes the basic situation of viruses and the structure and detection principle of FET biosensors. Subsequently, it delves into the research achievements in the application of FET biosensors in the detection of influenza viruses, hepatitis viruses, human immunodeficiency virus, and severe acute respiratory syndrome coronavirus 2. Finally, we make a comprehensive summary and reasonable outlook on the role played by FET biosensors in biomedicine.
