Progress in the regulation of mammalian embryonic development and reproduction by bone morphogenetic proteins.

Hongyu JIA; Honghong HE; Peng WANG; Xiaoxiao HUANG; Wenyi CAI; Yaying WANG; Jian LI; Daoliang LAN; Huizhu ZHANG

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Progress in the regulation of mammalian embryonic development and reproduction by bone morphogenetic proteins.

Author: Hongyu JIA ¹ ; Honghong HE ¹ ; Peng WANG ² ; Xiaoxiao HUANG ¹ ; Wenyi CAI ³ ; Yaying WANG ¹ ; Jian LI ¹ ; Daoliang LAN ¹ ; Huizhu ZHANG ¹
Author Information

1. College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, Sichuan, China.
2. Animal Husbandry Science Institute of Ganzi Tibetan Autonomous Prefecture, Kangding 626000, Sichuan, China.
3. Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization of Ministry of Education, Southwest Minzu University, Chengdu 610041, Sichuan, China.
Publication Type:English Abstract
Keywords: bone morphogenetic protein; embryonic development; female reproduction; oocyte
MeSH: Animals; Embryonic Development/drug effects*; Female; Bone Morphogenetic Proteins/pharmacology*; Reproduction/physiology*; Humans; Granulosa Cells/cytology*; Oocytes
From: Chinese Journal of Biotechnology 2025;41(7):2534-2544
CountryChina
Language:Chinese
Abstract: Bone morphogenetic proteins (BMPs) are multifunctional growth factors of the transforming growth factor β (TGF-β) superfamily. They regulate steroid secretion from mammalian granulosa cells, promote granulosa cell survival and proliferation, and inhibit follicular atresia, luteinization, and granulosa cell apoptosis, thereby promoting the development and maturation of mammalian follicles. At the same time, BMPs play an important role in embryonic morphogenesis, induction of uterine receptivity, and blastocyst attachment. This paper describes the effects of BMPs on mammalian follicular and embryonic development and the roles of BMPs in female reproduction, focusing on the process in which BMPs promote follicular maturation by regulating steroid secretion from granulosa cells during mammalian oocyte maturation. This review aims to provide a reference for further research on mammalian oocyte culture and improvement of reproductive efficiency in female animals.