Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus.
- Author:
Yu LIU
1
;
Sisi SU
1
;
Ziqian WANG
1
;
Jiahao WU
1
;
Hongwei CHEN
1
;
Hongzao YANG
1
Author Information
- Publication Type:English Abstract
- Keywords: PEDV; microbial metabolites; mixed infection; signaling pathways; viral proteins
- MeSH: Porcine epidemic diarrhea virus/immunology*; Animals; Swine; Swine Diseases/prevention & control*; Antiviral Agents/pharmacology*; Coronavirus Infections/virology*; Viral Vaccines/immunology*; Humans; Signal Transduction
- From: Chinese Journal of Biotechnology 2025;41(7):2519-2533
- CountryChina
- Language:Chinese
- Abstract: Porcine epidemic diarrhea virus (PEDV) is an intestinal coronavirus that can cause porcine epidemic diarrhea, leading to diarrhea, vomiting, weight loss, and even death in piglets. Due to the diversity of PEDV strains, traditional vaccines are difficult to sustainably and effectively prevent and control PEDV. This article reviews the strategies and mechanisms of active substances in regulating intracellular signaling pathways, viral proteins, and microbial metabolites to enhance the host immune function against PEDV. It emphasizes the prevention of PEDV resistance and the potential harm of PEDV breaking through interspecies barriers to the human society, aiming to provide reliable theoretical support for the development of new antiviral drugs or vaccines.
