Mining and dietary interventions of gut microbiota-derived metabolites.

Qixing NIE; Shanshan ZHANG; Chunhua CHEN; Jianqiao ZOU; Shaoping NIE

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Mining and dietary interventions of gut microbiota-derived metabolites.

Author: Qixing NIE ¹ ; Shanshan ZHANG ¹ ; Chunhua CHEN ¹ ; Jianqiao ZOU ¹ ; Shaoping NIE ¹
Author Information

1. State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology, Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, Jiangxi, China.
Publication Type:English Abstract
Keywords: dietary intervention; gut microbiota; metabolites; metabolomics
MeSH: Gastrointestinal Microbiome/physiology*; Humans; Dysbiosis/microbiology*; Metabolic Diseases/metabolism*; Diet
From: Chinese Journal of Biotechnology 2025;41(6):2275-2289
CountryChina
Language:Chinese
Abstract: The intestine is a complex symbiotic system, and the gut microbiota is closely related to host health. Studies have indicated that the gut microbiota influences physiological functions of the host by producing a variety of metabolites, which act as signaling molecules and substrates for metabolic reactions in the host. Dysbiosis of the gut microbiota affects the abundance of gut microbiota-derived metabolites, thereby influencing host health by disrupting signal transduction in multiple organs. Additionally, dietary compounds can shape the gut microbiota, affecting gut microbiota-derived metabolite levels and regulating host metabolism. This article introduces the methods for mining gut microbiota-derived metabolites, reviews the roles of these metabolites in metabolic diseases and related dietary interventions. Which provides a perspective on the prevention and treatment of metabolic diseases by targeting these metabolites, enriching the knowledge on the role of gut microbiota in the regulation of host metabolism.