<i>Pseudomonas monteilii</i> ZMU-T06 produces 2-substituted quinolines by oxidative dehydroaromatization.

Min YANG; Lan ZOU; Huimin RAN; Lei QIN

Return

Pseudomonas monteilii ZMU-T06 produces 2-substituted quinolines by oxidative dehydroaromatization.

Author: Min YANG ¹ ; Lan ZOU ¹ ; Huimin RAN ¹ ; Lei QIN ²
Author Information

1. The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi 563000, Guizhou, China.
2. Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi 563000, Guizhou, China.
Publication Type:Journal Article
Keywords: 2-substituted quinolines; catalytic mechanism; dehydroaromatization; monoamine oxidase
MeSH: Quinolines/chemistry*; Pseudomonas/classification*; Oxidation-Reduction; Monoamine Oxidase/biosynthesis*; Biocatalysis
From: Chinese Journal of Biotechnology 2025;41(1):288-295
CountryChina
Language:Chinese
Abstract: 2-substituted quinolines are the building blocks for the synthesis of natural products and pharmaceuticals. In comparison with classical methods, dehydroaromatization of 2-substituted-1,2,3,4-tetrahydroquinolines has emerged in recent years as an efficient and straightforward method to synthesize quinolines due to its high atom economy and sustainability. However, existing chemical methods need transition metal catalysts and harsh reaction conditions. Biocatalysis with high efficiency, high selectivity, and mild reaction conditions has become an important method of organic synthesis. We mined a strain Pseudomonas monteilii ZMU-T06 capable of producing monoamine oxidase for the dehydroaromatization of 2-substituted-1,2,3,4-tetrahydroquinolines to synthesize 2-substituted quinolines (8 substrates, yields of 45.7%-48.4%) and then hypothesized the catalytic mechanism, providing a new method for green synthesis of 2-substituted quinolines.