Research progress in animal embryo implantation and endometrial organoids.

Jingyi TU; Changqing SHEN; Ruiling LEI; Jie YANG; Shicheng WANG; Siqi PENG; Lang LI; Xiaoyan QIU

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Research progress in animal embryo implantation and endometrial organoids.

Author: Jingyi TU ¹ ; Changqing SHEN ¹ ; Ruiling LEI ¹ ; Jie YANG ² ; Shicheng WANG ¹ ; Siqi PENG ¹ ; Lang LI ¹ ; Xiaoyan QIU ¹
Author Information

1. Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
2. Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China.
Publication Type:English Abstract
Keywords: embryo implantation; endometrial assembloids; endometrial organoids; endometrium
MeSH: Endometrium/physiology*; Organoids/cytology*; Embryo Implantation/physiology*; Female; Animals; Progesterone/pharmacology*; Pregnancy; Estrogens/metabolism*; Humans
From: Chinese Journal of Biotechnology 2024;40(12):4452-4466
CountryChina
Language:Chinese
Abstract: Embryo implantation involves a complex interaction between the embryo and the endometrium of the mother, the study of which faces a variety of problems. The modeling of endometrial epithelial organoids and endometrial assembloids provides a new way to study the process of embryo implantation in vitro. This paper summarized the latest research progress in embryo implantation, the regulation mechanism of endometrial receptivity by estrogen- progesterone coordination and embryo-derived signals, the establishment of endometrial organoids, and the development and application of endometrial assembloids in the research on mother-embryo interaction, providing new strategies for studying the communication between embryo and maternal uterus during implantation.