Advances in the anti-host interferon immune response of bluetongue virus.

Author: Qisha LI ¹ ; Xuyan CAI ¹ ; Shimei LUO ¹ ; Yunyi CHEN ¹ ; Huashan YI ¹ ; Xianping MA ¹
Author Information

1. College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Publication Type:English Abstract
Keywords: antiviral immunity; bluetongue virus; interferon (IFN) immune response; non-structural protein; virus-host interaction
MeSH: Bluetongue virus/immunology*; Animals; Bluetongue/prevention & control*; Immunity, Innate; Interferons/immunology*; Sheep; Viral Nonstructural Proteins/immunology*; Cattle
From: Chinese Journal of Biotechnology 2024;40(12):4439-4451
CountryChina
Language:Chinese
Abstract: Bluetongue virus (BTV) usually infects sheep, cattle, deer and other domesticated and wild ruminants through the bite of the vector insects, Culicoide, causing bluetongue (BT). BT in subtropical and even temperate regions poses a serious threat to the development and international trade of the livestock industry. This article introduced the structure and cellular invasion, and summarized the mechanisms of anti-BTV immune response of host cells and antagonism of host cell innate immune response by the non-structural proteins (e.g., NS3 and NS4) and structural proteins (e.g., VP3 and VP4) of BTV. This review provided a basis for understanding the antagonism mechanisms of BTV against the interferon (IFN) immune response in the host cell and the pathogenesis of BTV as well as for developing novel vaccines against this virus.