Research progress in biological activities and oocyte aging-regulating effect of EGCG.

Author: Weiying ZHANG ¹ ; Huizhu ZHANG ¹ ; Yujun LI ¹ ; Daoliang LAN ¹ ; Xianrong XIONG ¹ ; Yaying WANG ¹ ; Jian LI ¹ ; Honghong HE ¹
Author Information

1. College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, Sichuan, China.
Publication Type:English Abstract
Keywords: antioxidant; epigallocatechin gallate (EGCG); oocyte aging; oxidative stress
MeSH: Catechin/pharmacology*; Oocytes/metabolism*; Humans; Animals; Antioxidants/pharmacology*; Female; Cellular Senescence/drug effects*; Tea/chemistry*; Apoptosis/drug effects*
From: Chinese Journal of Biotechnology 2024;40(12):4382-4395
CountryChina
Language:Chinese
Abstract: Epigallocatechin gallate (EGCG), the predominant polyphenol in green tea, exerts a spectrum of physiological activities, including antioxidant, anticancer, and anti-inflammatory effects. Emerging research underscores the significance of EGCG in modulating oocyte aging. EGCG can enhance antioxidant defenses, improve mitochondrial functions, and inhibit apoptotic pathways, thereby retarding the aging of oocytes. This review delineates the main molecular features of EGCG and expounds its regulatory mechanisms concerning oocyte aging, enriching the knowledge on the role of EGCG in the amelioration of oocyte aging.