Research progress in polysaccharide-modified lipid nanoparticles for drug delivery.
- Author:
Yuqing MA
1
;
Haiyun LIU
1
;
Xiaoqiang WANG
2
;
Shiqi SUN
1
;
Huichen GUO
1
Author Information
- Publication Type:English Abstract
- Keywords: drug delivery system; lipid nanoparticles; polysaccharide applications; polysaccharide modification; preparation of lipid nanoparticles
- MeSH: Polysaccharides/chemistry*; Nanoparticles/chemistry*; Lipids/chemistry*; Drug Delivery Systems; Humans; Drug Carriers/chemistry*
- From: Chinese Journal of Biotechnology 2024;40(12):4339-4350
- CountryChina
- Language:Chinese
- Abstract: Lipid nanoparticles serve as a promising drug delivery system due to the good biocompatibility, non-immunogenicity, and high drug loading efficiency. However, unmodified lipid nanoparticles have limitations such as poor stability, easy hydrolysis, and rapid removal. To overcome these shortcomings, researchers have developed peptide modification, antibody modification, ligand modification, nucleic acid aptamer modification, and polysaccharide modification for lipid nanoparticles. Polysaccharides are a class of natural polymers, and the polysaccharide-modified lipid nanoparticles exhibit good biocompatibility, precise targeting, and low toxicity. Therefore, polysaccharide-modified lipid nanoparticles demonstrate great potential in clinical treatment. This review summarizes the preparation and application of polysaccharide-modified lipid nanoparticles, aiming to provide a reference for further research and development of new lipid nanoparticles.
