Advances in prostate cancer biomarkers.

Zibin CHU; Ye XU; Ziqiang YIN; Jingfeng CAO; Chengyu JIN; Xiaoyang CHEN; Zhao YANG

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Advances in prostate cancer biomarkers.

Author: Zibin CHU ¹ ; Ye XU ¹ ; Ziqiang YIN ¹ ; Jingfeng CAO ¹ ; Chengyu JIN ¹ ; Xiaoyang CHEN ¹ ; Zhao YANG ¹
Author Information

1. Innovation Center of Molecular Diagnostics, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Publication Type:English Abstract
Keywords: biomarkers; diagnosis; prognostic evaluation; prostate cancer; prostate-specific antigen
MeSH: Humans; Male; Prostatic Neoplasms/diagnosis*; Biomarkers, Tumor/blood*; Early Detection of Cancer/methods*; Prognosis; Prostate-Specific Antigen/blood*; Glutamate Carboxypeptidase II/metabolism*; Antigens, Neoplasm/blood*; Antigens, Surface; Serine Endopeptidases
From: Chinese Journal of Biotechnology 2024;40(11):3951-3973
CountryChina
Language:Chinese
Abstract: Prostate cancer is one of the most common malignant tumors in men and posing a serious threat to men's health. Detection methods such as prostate-specific antigen (PSA), prostate biopsy, and magnetic resonance imaging are widely used for prostate cancer screening, but they have low specificity, high cost, and significant risks. Therefore, there is an urgent need to develop highly specific, low-cost, easily obtained, stable, and reliable biomarkers, and use them as the basis to establish non-invasive screening and diagnostic methods for prostate cancer. This paper reviewed the recent advances in the use of prostate cancer biomarkers and combined detection methods for prostate cancer diagnosis and prognosis assessment and provides an in-depth analysis and comparison of different biomarkers and combined detection methods, as well as points out the directions and challenges for future research. The paper emphasizes the importance of developing efficient, cost-effective and easy-to-implement biomarkers to increase the early diagnosis rate of prostate cancer, improve patient prognosis, and reduce the waste of healthcare resources. This paper provides an important theoretical basis and technical guidance for early diagnosis, precise treatment and prognostic evaluation of prostate cancer, and has important reference value for promoting clinical research and practice of prostate cancer.