Research progress in the translation efficiency of mRNA vaccines.

Author: Tao LIU ¹ ; Shengqi WANG ¹ ; Wuju LI ¹
Author Information

1. Bioinformatics Center of Academy of Military Medical Sciences, Beijing 100850, China.
Publication Type:English Abstract
Keywords: expression; mRNA; translation; vaccine
MeSH: mRNA Vaccines; Humans; Protein Biosynthesis; Vaccines, Synthetic/immunology*; COVID-19 Vaccines/immunology*; COVID-19/prevention & control*; SARS-CoV-2/genetics*; RNA, Messenger/genetics*
From: Chinese Journal of Biotechnology 2024;40(11):3930-3950
CountryChina
Language:Chinese
Abstract: Compared with conventional vaccines, mRNA vaccines have considerable advantages in design, production, and application, especially in dealing with emerging infectious diseases. Particularly, mRNA vaccines were the first to be recommended by the World Health Organization for emergency use during the COVID-19 pandemic. A key to the design of mRNA vaccines is to ensure the stable and sufficient expression of the encoded protein in the recipient. In recent years, advances have been attained in the experimental and computational research in this area. This review focused on the progress and problems in improving the translation efficiency of mRNA vaccines in recent years, aiming to promote related research.