Research progress in the small G-protein Rac1.

Author: Yiheng YANG ¹ ; Shuling ZHAO ¹ ; Changyong LIANG ¹
Author Information

1. College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225100, Jiangsu, China.
Publication Type:English Abstract
Keywords: Rac1; cytoskeleton; tumor; virus
MeSH: Humans; rac1 GTP-Binding Protein/genetics*; Virus Replication; Glioma/pathology*; Actin Cytoskeleton/metabolism*; Animals
From: Chinese Journal of Biotechnology 2024;40(11):3902-3911
CountryChina
Language:Chinese
Abstract: The small G-protein Rac1 is the main regulatory factor of the actin cytoskeleton. Rac1 cycles between the inactive GDP-bound form and the active GTP-bound form. Rac1 not only promotes viral replication and infection, but also regulates the actin cytoskeleton rearrangement, adhesion, and invasion of glioma cells. In addition, Rac1 is implicated in human diseases such as tumors and epilepsy. This article reviews the latest research on the small G-protein Rac1 in virology, cell biology, and human pathology. It is found that the existence of Rac1 is closely related to the replication and infection of viruses, that is, inhibiting the existence of Rac1 can effectively reduce the replication and transportation of viruses, providing new ideas for the development of various therapeutic drugs targeting Rac1.