Advances in the application of live bacteria as vehicles for delivering antitumor drugs.

Author: Tingting HUA ¹ ; Bin ZHENG ¹ ; Yang BAI ¹
Author Information

1. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Publication Type:English Abstract
Keywords: delivery strategies; drugs; engineered bacteria; live bacteria; tumors
MeSH: Antineoplastic Agents; Humans; Drug Delivery Systems; Neoplasms/drug therapy*; Drug Carriers; Bacteria/metabolism*; Animals
From: Chinese Journal of Biotechnology 2024;40(11):3861-3871
CountryChina
Language:Chinese
Abstract: Some bacteria can selectively colonize the tumor site and inhibit tumor growth, serving as ideal vehicles for delivering antitumor drugs. The system of delivering antitumor drugs with live bacteria as vehicles is characterized by good biocompatibility and precise targeting. However, the development of bacteria as drug delivery vehicles is limited by their own immunogenicity. In this paper, the selection of chassis bacteria, bacterial loading drug strategies, antitumor drug delivery applications and their limitations are elaborated in detail, and its future development direction is envisioned, with a view to providing a reference for the study of live bacteria as antitumor drug delivery carriers.