Progress in clinicopathological diagnosis of oral potentially malignant disorders.
10.7518/hxkq.2025.2024427
- Author:
Yingying CUI
1
;
Chuanyang DING
1
;
Chaoran PENG
2
;
Jianyun ZHANG
2
;
Xinjia CAI
1
;
Tiejun LI
2
Author Information
1. Central Laboratory, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China.
2. Dept. of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China.
- Publication Type:English Abstract
- Keywords:
oral leukoplakia;
oral lichen planus;
oral potentially malignant disorders;
oral submucous fibrosis;
proliferative verrucous leukoplakia
- MeSH:
Humans;
Mouth Neoplasms/diagnosis*;
Precancerous Conditions/diagnosis*;
Leukoplakia, Oral/diagnosis*;
Lichen Planus, Oral/pathology*;
Oral Submucous Fibrosis/pathology*;
Mouth Mucosa/pathology*;
World Health Organization
- From:
West China Journal of Stomatology
2025;43(3):314-324
- CountryChina
- Language:Chinese
-
Abstract:
As the field of oral pathology has evolved, the nomenclature and classification of oral mucosal diseases with a remarkable risk of malignant transformation have undergone several modifications. In 2005, the World Health Organization (WHO) introduced the concept of oral potentially malignant disorders (OPMDs) as an alternative to the terms for oral precancerous lesions and precancerous conditions. In the consensus report by the WHO Collaborating Center for Oral Cancer of 2021, OPMD is defined as "any oral mucosal abnormality that is associated with a statistically increased risk of developing oral cancer."This definition encompasses a range of conditions, in-cluding oral leukoplakia, oral submucous fibrosis, proliferative verrucous leukoplakia, oral lichen planus, and other lesions. In light of the complex etiology, unclear pathogenesis, and carcinogenesis of OPMDs, early and precise diagnosis and treatment can contribute to the secondary prevention of oral cancer. For this reason, this review, which aims to provide a basis for the precise clinical diagnosis of OPMDs, was performed. Its aim was achieved by reviewing the historical evolution and research progress of the nomenclature, classification, and histopathological diagnostic criteria of OPMDs.
